Recent DIPG Research News

Finding a cure through funding vital research

There are currently very few treatments showing any efficacy (scientifically documented and proven) and no cure available for DIPG

Research initiatives and funding of this work enabling doctors to get a better understanding of how DIPG develops and progresses, is the only way to lead development of effective treatment options, and techniques to benefit ALL children affected by DIPG.

Here are some of the latest developments : 

Influence of an intratumoral cyst on drug distribution by convection-enhanced delivery: case report

http://thejns.org/doi/abs/10.3171/2017.5.PEDS1774 

Pediatric Gliomas: Current Concepts on Diagnosis, Biology, and Clinical Management

http://ascopubs.org/doi/full/10.1200/JCO.2017.73.0242 

Restoring the tumor suppressor gene p16 slows tumor growth in vitro

https://www.sciencedaily.com/releases/2017/06/170606155728.htm 

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas.

https://www.ncbi.nlm.nih.gov/pubmed/28263309 

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

http://www.nature.com/nm/journal/v23/n4/full/nm.4296.html 

Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors

http://stm.sciencemag.org/content/9/381/eaaf2968 

BMI-1 is a Potential Therapeutic Target in Diffuse Intrinsic Pontine Glioma

https://www.ncbi.nlm.nih.gov/pubmed/28591729 

A phase I study of convection enhanced delivery (CED) of 124I-8H9 radio-labeled monoclonal antibody in children with diffuse intrinsic pontine glioma (DIPG).

http://ascopubs.org/doi/abs/10.1200/JCO.2017.35.15_suppl.2010 

External validation of the diffuse intrinsic pontine glioma survival prediction model: a collaborative report from the International DIPG Registry and the SIOPE DIPG Registry.

https://www.ncbi.nlm.nih.gov/labs/articles/28560664/ 

Repurposing the anti-epileptic drug sodium valproate as an adjuvant treatment for diffuse intrinsic pontine glioma

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176855

 Pre-Clinical Study of Panobinostat in Xenograft and Genetically Engineered Murine Diffuse Intrinsic Pontine Glioma Models

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169485